PLoS One. Published online May Stott Parker Arthur W. Performed the experiments:
PLoS One. Published online May Stott Parker Arthur W. Performed the experiments: ID DR. Analyzed the data: Wrote the paper: Received Feb 20; Accepted Mar Copyright Dinov et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
This article has been cited by other articles in PMC. Abstract The advancement of the computational biology field hinges on progress in three fundamental directions — the development of new computational algorithms, the availability of informatics resource management infrastructures and the capability of tools to interoperate and synergize.
There is an explosion in algorithms and tools for computational biology, which makes it difficult for biologists to find, compare and integrate such resources. We describe a new infrastructure, iTools, for managing the query, traversal and comparison of diverse computational biology resources. Specifically, iTools stores information about three types of resources—data, software tools and web-services.
The iTools design, implementation and resource meta – data content reflect the broad research, computational, applied and scientific expertise available at the seven National Centers for Biomedical Computing. A large number of resources are already iTools-accessible to the community and this infrastructure is rapidly growing. Investigators or computer programs may utilize these interfaces to search, compare, expand, revise and mine meta-data descriptions of existent computational biology resources.
We propose two ways to browse and display the iTools dynamic collection of resources. The first one is based on an ontology of computational biology resources, and the second one is derived from hyperbolic projections of manifolds or complex structures onto planar discs. We demonstrate several applications of iTools as a framework for integrated bioinformatics. Introduction Bioinformatics is quickly becoming the central core that integrates the many disparate bodies of data, scientific knowledge and computational infrastructure from fields as diverse as genetics, structural biology, medical and animal models of disease, imaging, engineering, etc.
For example, biological imaging and shape representation  —  , sequence analysis  , regulatory genomics  and alternative splicing  are critical components of computational biology. Many space, time, function or interaction modeling techniques apply across the vast spectrum of scales from genotypes to phenotypes, from the small scale of microarray imaging for genomics, to the larger in vivo neuroimaging scale.
In this manuscript, we discuss challenges of development, maintenance and dissemination of robust computational biology resources data, tools and services, see below. The rapid growth, usage specifications, application domain and method diversity of contemporary computational biology resources presents an impediment to finding, comparing and integrating such data and tools.
We propose a new decentralized, extensible, lightweight, scalable and portable framework iTools to enable resource location, management, evaluation and mediation. There is an increasing need in the bioinformatics community for accurate accounting of data and resources, e. We leveraged the broad research, computational, applied and scientific expertise available at the seven National Centers for Biomedical Computing NCBC to design, implement and validate a new schema for classifying, categorizing and integrating different computational biology resources across space-and-time scales, biomedical problems, computational infrastructures and mathematical foundations.
The proposed infrastructure is not limited to needs and applications of the NCBCs. Rather it is intentionally designed to be extensible and applicable to broader range of biomedical research.
The computational biology research at these centers and their partner and collaborating institutions spans a wide range, which ensures that the NCBC program provides a foundation for a National infrastructure for diverse biomedical computing. The research and clinical goals, project descriptions, home-pages and the computational infrastructures provided by of all NCBC centers is available online at http: Current approaches for software tool classification, categorization and integration There are a number of efforts to develop integrated resources that provide a common user-friendly access to variety of tools and software programs for computational biology.
Table 1 summarizes many of these attempts. These are important efforts to catalog computational tools; however, there are remaining challenges, whose solutions may significantly affect both the development of new tools and technologies and the utilization of existent novel computational biology resources. For example, there is no one-stop site for researchers to go to search, contrast and integrate tools.
Many sites specialize on certain types of tools, and researchers must know about these sites to find the tools they seek. In addition, graphical traversal, semantic search, and effective interfaces for tool integration are still mostly envisioned for the future. Research progress also may be significantly potentiated by providing agile interfaces, extensibility and portability features to any new meta-resource of computational biology tools and software.
The itools library. itools License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version. iTools. Configuration and monitoring software. Help Manual. EUROTHERM .. Promote Parameters. portion of each window is given over to parameter help. Page 8. HA Issue 1 Feb 05 to a clone file, and then to send this clone file to an instrument if required. HA Page 9. Issue 1 Feb iTools is a small app that allows you to manage your iOS devices through an intuitive interface via your Windows Screenshot 1 Screenshot 2.
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iTools is a simple and complete solution to manage your iPad, iPhone, iPad or iPod Touch without .com/system-tuning-utilities-tools/utilities-tools/itools-pro/ itools-prohtml 8 nhận xét: Amila Senakumara October 23, at PM. iTools For Mac & Windows: iOS / / Free Download. iTools. Configuration and monitoring software. Help Manual. EUROTHERM .. Promote Parameters. portion of each window is given over to parameter help. Page 8. HA Issue 1 Feb 05 to a clone file, and then to send this clone file to an instrument if required. HA Page 9. Issue 1 Feb For example, biological imaging and shape representation –, . Web Service Definition Language (WSDL), BioMOBY , etc. Tools (software resources) consist of computational algorithms (e.g., Level-sets, ), software.